Acuity of a Cryptochrome and Vision-Based Magnetoreception System in Birds

Journal Article

Title: Acuity of a Cryptochrome and Vision-Based Magnetoreception System in Birds
Publication Date:
July 01, 2010
Journal: Biophysical Journal
Volume: 99
Issue: 1
Pages: 40-49
Publisher: Cell Press
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Document Access

Website: External Link
Attachment: Access File
(663 KB)

Citation

Solov'yov, I.; Mouritsen, H.; Schulten, K. (2010). Acuity of a Cryptochrome and Vision-Based Magnetoreception System in Birds. Biophysical Journal, 99(1), 40-49.
Abstract: 

The magnetic compass of birds is embedded in the visual system and it has been hypothesized that the primary sensory mechanism is based on a radical pair reaction. Previous models of magnetoreception have assumed that the radical pair-forming molecules are rigidly fixed in space, and this assumption has been a major objection to the suggested hypothesis. In this article, we investigate theoretically how much disorder is permitted for the radical pair-forming, protein-based magnetic compass in the eye to remain functional. Our study shows that only one rotational degree of freedom of the radical pair-forming protein needs to be partially constrained, while the other two rotational degrees of freedom do not impact the magnetoreceptive properties of the protein. The result implies that any membrane-associated protein is sufficiently restricted in its motion to function as a radical pair-based magnetoreceptor. We relate our theoretical findings to the cryptochromes, currently considered the likeliest candidate to furnish radical pair-based magnetoreception.

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