In the present article, a new methodological framework for the efficient and sustainable exploitation of offshore wind potential was developed. The proposed integrated strategic plan was implemented for the first time at national spatial planning scale in Greece. The methodological approach is performed through geographical information systems (GIS) and Microsoft Project Server Software and includes five distinct stages: (i) definition of vision/mission, (ii) identification of appropriate areas for offshore wind farms’ (OWFs) siting, (iii) determination of the OWFs’ layout, (iv) calculation of the OWFs’ (projects) total investment cost and, finally, (v) portfolio analysis. The final outcome of the proposed strategic planning is the prioritization of the proposed sixteen offshore wind projects based on their strategic value, as well as the estimation of the overall investment cost of the entire portfolio. High economic, socio-political and environmental benefits could be achieved through the implementation of only 60% of the total investment capital of the proposed strategic plan.