Wind-generated power is one of the fastest growing alternative energy strategies worldwide and will likely account for 20% of US energy production by 2030. The installation and maintenance of wind farms are associated with increased human activity and can generate noise pollution, disturb and fragment habitat, and even alter community composition and structure. These environmental and ecological changes can increase physiological stress for vertebrates and affect important life-history attributes, such as immune function. However, little is known about how wind farms influence physiology and disease or parasite resistance in nonvolant wildlife. Here, we test the notion that renewable wind farms increase physiological stress and correlated aspects of disease resistance (parasite load) in a common desert vertebrate, the side-blotched lizard (Uta stansburiana). We captured lizards from three wind farms and three undisturbed reference sites in the San Gorgonio Pass wind resource area in the Mojave Desert, California. We quantified individual external parasite loads and measured plasma antioxidant capacity and concentrations of reactive oxygen metabolites as a combined metric of oxidative stress. Contrary to our expectations, individuals at wind farm sites had significantly fewer external parasites than at undeveloped sites. Additionally, we found a slight positive correlation between parasite load and oxidative stress for individuals at wind farm sites but not at reference sites. Our results demonstrate a complex, potentially context-dependent relationship between stress physiology and disease resistance for lizards in anthropogenically disturbed environments. Understanding how wind farms affect the physiology and ecoimmunology of terrestrial fauna is necessary to mitigate the ecological costs of alternative energy development.